Amine functionalized nanodiamond promotes cellular adhesion, proliferation and neurite outgrowth.

نویسندگان

  • A P Hopper
  • J M Dugan
  • A A Gill
  • O J L Fox
  • P W May
  • J W Haycock
  • F Claeyssens
چکیده

In this study, we report the production of amine functionalized nanodiamond. The amine functionalized nanodiamond forms a conformal monolayer on a negatively charged surface produced via plasma polymerization of acrylic acid. Nanodiamond terminated surfaces were studied as substrates for neuronal cell culture. NG108-15 neuroblastoma-glioma hybrid cells were successfully cultured upon amine functionalized nanodiamond coated surfaces for between 1 and 7 d. Additionally, primary dorsal root ganglion (DRG) neurons and Schwann cells isolated from Wistar rats were also successfully cultured over a period of 21 d illustrating the potential of the coating for applications in the treatment of peripheral nerve injury.

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عنوان ژورنال:
  • Biomedical materials

دوره 9 4  شماره 

صفحات  -

تاریخ انتشار 2014